Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620429
Title:
Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.
Authors:
Gillespie, A. L.; Samanaite, R.; Mill, Jonathan; Egerton, A.; MacCabe, J. H.
Abstract:
Schizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak dopamine antagonism. It is plausible that varying degrees of response to antipsychotics reflect categorically distinct illness subtypes, which would have significant implications for research and clinical practice. If these subtypes could be distinguished at illness onset, this could represent a first step towards personalised medicine in psychiatry. This systematic review investigates whether current evidence supports conceptualising treatment-resistant and treatment-responsive schizophrenoa as categorically distinct subtypes.
Citation:
Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review. 2017, 17 (1):12 BMC Psychiatry
Publisher:
BioMed Central
Journal:
BMC Psychiatry
Issue Date:
13-Jan-2017
URI:
http://hdl.handle.net/11287/620429
DOI:
10.1186/s12888-016-1177-y
PubMed ID:
28086761
Additional Links:
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1177-y
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site
Type:
Journal Article
Language:
en
ISSN:
1471-244X
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGillespie, A. L.en
dc.contributor.authorSamanaite, R.en
dc.contributor.authorMill, Jonathanen
dc.contributor.authorEgerton, A.en
dc.contributor.authorMacCabe, J. H.en
dc.date.accessioned2017-10-11T14:44:03Z-
dc.date.available2017-10-11T14:44:03Z-
dc.date.issued2017-01-13-
dc.identifier.citationIs treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review. 2017, 17 (1):12 BMC Psychiatryen
dc.identifier.issn1471-244X-
dc.identifier.pmid28086761-
dc.identifier.doi10.1186/s12888-016-1177-y-
dc.identifier.urihttp://hdl.handle.net/11287/620429-
dc.description.abstractSchizophrenia is a highly heterogeneous disorder, and around a third of patients are treatment-resistant. The only evidence-based treatment for these patients is clozapine, an atypical antipsychotic with relatively weak dopamine antagonism. It is plausible that varying degrees of response to antipsychotics reflect categorically distinct illness subtypes, which would have significant implications for research and clinical practice. If these subtypes could be distinguished at illness onset, this could represent a first step towards personalised medicine in psychiatry. This systematic review investigates whether current evidence supports conceptualising treatment-resistant and treatment-responsive schizophrenoa as categorically distinct subtypes.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1177-yen
dc.rightsArchived with thanks to BMC psychiatryen
dc.subjectWessex Classification Subject Headings::Mental healthen
dc.subject.meshAntipsychotic Agents-
dc.subject.meshClinical Trials as Topic-
dc.subject.meshClozapine-
dc.subject.meshHumans-
dc.subject.meshProspective Studies-
dc.subject.meshSchizophrenia-
dc.subject.meshTreatment Outcome-
dc.titleIs treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? a systematic review.en
dc.typeJournal Articleen
dc.identifier.journalBMC Psychiatryen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's siteen
dc.type.versionPublisheden

Related articles on PubMed

All Items in RD&E Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.