Noninvasive Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Based on Sample Differential Transmittance.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620435
Title:
Noninvasive Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Based on Sample Differential Transmittance.
Authors:
Gardner, B.; Stone, Nick; Matousek, P.
Abstract:
Here we propose a simple noninvasive approach to determine the depth of a buried object using transmission Raman spectroscopy. In accordance with theory, the photons arising from spectral peaks that are suitably separated will be subjected to different optical properties in the media through which they travel. These differences can impact the relative intensities of Raman peaks as a function of the transmission path length, thereby the depth of signal generation is inherently encoded in the spectra. In a proof-of-concept study, through only external calibrations, it was possible to accurately predict the depth of Polytetrafluoroethylene (PTFE) layer purely on the basis of relative intensity of two peaks in a predominantly absorbing solution Indian ink (0.1 μL/mL; RMSE 0.42 mm) and a scattering solution (RMSE 0.50 mm). This simple approach offers the possibility to noninvasively identify the depth of a buried object, such as breast calcifications, using simple transmission measurement geometries for the first time.
Citation:
Noninvasive Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Based on Sample Differential Transmittance. 2017, 89 (18):9730-9733 Anal. Chem.
Publisher:
American Chemical Society
Journal:
Analytical chemistry
Issue Date:
19-Sep-2017
URI:
http://hdl.handle.net/11287/620435
DOI:
10.1021/acs.analchem.7b01469
PubMed ID:
28825475
Additional Links:
https://dx.doi.org/10.1021/acs.analchem.7b01469
Type:
Journal Article
Language:
en
ISSN:
1520-6882
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGardner, B.en
dc.contributor.authorStone, Nicken
dc.contributor.authorMatousek, P.en
dc.date.accessioned2017-10-11T15:04:31Z-
dc.date.available2017-10-11T15:04:31Z-
dc.date.issued2017-09-19-
dc.identifier.citationNoninvasive Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Based on Sample Differential Transmittance. 2017, 89 (18):9730-9733 Anal. Chem.en
dc.identifier.issn1520-6882-
dc.identifier.pmid28825475-
dc.identifier.doi10.1021/acs.analchem.7b01469-
dc.identifier.urihttp://hdl.handle.net/11287/620435-
dc.description.abstractHere we propose a simple noninvasive approach to determine the depth of a buried object using transmission Raman spectroscopy. In accordance with theory, the photons arising from spectral peaks that are suitably separated will be subjected to different optical properties in the media through which they travel. These differences can impact the relative intensities of Raman peaks as a function of the transmission path length, thereby the depth of signal generation is inherently encoded in the spectra. In a proof-of-concept study, through only external calibrations, it was possible to accurately predict the depth of Polytetrafluoroethylene (PTFE) layer purely on the basis of relative intensity of two peaks in a predominantly absorbing solution Indian ink (0.1 μL/mL; RMSE 0.42 mm) and a scattering solution (RMSE 0.50 mm). This simple approach offers the possibility to noninvasively identify the depth of a buried object, such as breast calcifications, using simple transmission measurement geometries for the first time.en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.relation.urlhttps://dx.doi.org/10.1021/acs.analchem.7b01469en
dc.rightsArchived with thanks to Analytical chemistryen
dc.subjectWessex Classification Subject Headings::Biochemistryen
dc.titleNoninvasive Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Based on Sample Differential Transmittance.en
dc.typeJournal Articleen
dc.identifier.journalAnalytical chemistryen
dc.type.versionPublisheden
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