Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620436
Title:
Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element.
Authors:
Vardaki, M. Z.; Sheridan, H.; Stone, Nick; Matousek, P.
Abstract:
This study demonstrates experimentally a method to enable prediction of depth of a chemical species buried in a turbid medium by using transmission Raman spectroscopy alone. The method allows the prediction of the depth of a single, chemically distinct layer within a turbid matrix by performing two measurements, with and without a beam enhancing element, or "photon diode." The samples employed consisted of two different polymers, of total thickness 3.6 mm, whose optical properties are loosely relevant to pharmaceutical applications. A polymer layer of low-density polyethylene (LDPE) was placed at different positions within multiple layers of the polytetrafluoroethylene (PTFE) matrix and Raman spectra were recorded in each case. Both univariate and multivariate analyses were utilized to determine whether the depth of the LDPE layer could be predicted using the obtained data. The best-achieved RMSE of prediction was 4.2% of the total sample size (i.e., +/- 0.15 mm) with the multivariate approach.
Citation:
Determination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element. 2017, 71 (8):1849-1855 Appl Spectrosc
Publisher:
Sage
Journal:
Applied spectroscopy
Issue Date:
Aug-2017
URI:
http://hdl.handle.net/11287/620436
DOI:
10.1177/0003702817691540
PubMed ID:
28756706
Additional Links:
http://journals.sagepub.com/doi/abs/10.1177/0003702817691540?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Type:
Journal Article
Language:
en
ISSN:
1943-3530
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorVardaki, M. Z.en
dc.contributor.authorSheridan, H.en
dc.contributor.authorStone, Nicken
dc.contributor.authorMatousek, P.en
dc.date.accessioned2017-10-11T15:06:38Z-
dc.date.available2017-10-11T15:06:38Z-
dc.date.issued2017-08-
dc.identifier.citationDetermination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element. 2017, 71 (8):1849-1855 Appl Spectroscen
dc.identifier.issn1943-3530-
dc.identifier.pmid28756706-
dc.identifier.doi10.1177/0003702817691540-
dc.identifier.urihttp://hdl.handle.net/11287/620436-
dc.description.abstractThis study demonstrates experimentally a method to enable prediction of depth of a chemical species buried in a turbid medium by using transmission Raman spectroscopy alone. The method allows the prediction of the depth of a single, chemically distinct layer within a turbid matrix by performing two measurements, with and without a beam enhancing element, or "photon diode." The samples employed consisted of two different polymers, of total thickness 3.6 mm, whose optical properties are loosely relevant to pharmaceutical applications. A polymer layer of low-density polyethylene (LDPE) was placed at different positions within multiple layers of the polytetrafluoroethylene (PTFE) matrix and Raman spectra were recorded in each case. Both univariate and multivariate analyses were utilized to determine whether the depth of the LDPE layer could be predicted using the obtained data. The best-achieved RMSE of prediction was 4.2% of the total sample size (i.e., +/- 0.15 mm) with the multivariate approach.en
dc.language.isoenen
dc.publisherSageen
dc.relation.urlhttp://journals.sagepub.com/doi/abs/10.1177/0003702817691540?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmeden
dc.rightsArchived with thanks to Applied spectroscopyen
dc.subjectWessex Classification Subject Headings::Biochemistryen
dc.titleDetermination of Depth in Transmission Raman Spectroscopy in Turbid Media Using a Beam Enhancing Element.en
dc.typeJournal Articleen
dc.identifier.journalApplied spectroscopyen
dc.type.versionPublisheden

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