High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620438
Title:
High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy.
Authors:
Ghita, A.; Matousek, P.; Stone, Nick
Abstract:
The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy. However, this information is not available from mammography, leading to excisional biopsy and histopathological assessment for a definitive diagnosis. Here we present, for the first time, a design of a new high performance deep Raman instrument and demonstrate its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue. This is around double the penetration depth achieved with our previous instrument design and around two orders of magnitude higher than that possible when using conventional Raman spectroscopy.
Citation:
High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy. 2017 J Biophotonics
Publisher:
Wiley
Journal:
Journal of biophotonics
Issue Date:
21-Jun-2017
URI:
http://hdl.handle.net/11287/620438
DOI:
10.1002/jbio.201600260
PubMed ID:
28635141
Additional Links:
http://dx.doi.org/10.1002/jbio.201600260
Type:
Journal Article
Language:
en
ISSN:
1864-0648
Appears in Collections:
Honorary contracts publications; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorGhita, A.en
dc.contributor.authorMatousek, P.en
dc.contributor.authorStone, Nicken
dc.date.accessioned2017-10-11T15:10:22Z-
dc.date.available2017-10-11T15:10:22Z-
dc.date.issued2017-06-21-
dc.identifier.citationHigh sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy. 2017 J Biophotonicsen
dc.identifier.issn1864-0648-
dc.identifier.pmid28635141-
dc.identifier.doi10.1002/jbio.201600260-
dc.identifier.urihttp://hdl.handle.net/11287/620438-
dc.description.abstractThe aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. The chemical composition of a breast calcification reflects the pathology of the surrounding tissue, malignant or benign and potentially the grade of malignancy. However, this information is not available from mammography, leading to excisional biopsy and histopathological assessment for a definitive diagnosis. Here we present, for the first time, a design of a new high performance deep Raman instrument and demonstrate its capability to detect type II calcifications (calcium hydroxyapatite) at clinically relevant concentrations and depths of around 40 mm in phantom tissue. This is around double the penetration depth achieved with our previous instrument design and around two orders of magnitude higher than that possible when using conventional Raman spectroscopy.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://dx.doi.org/10.1002/jbio.201600260en
dc.rightsArchived with thanks to Journal of biophotonicsen
dc.subjectWessex Classification Subject Headings::Biochemistryen
dc.titleHigh sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy.en
dc.typeJournal Articleen
dc.identifier.journalJournal of biophotonicsen
dc.type.versionIn press (epub ahead of print)en
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