DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620442
Title:
DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning.
Authors:
Chen, Y-T; Wallace, Christopher G ( 0000-0003-1897-9520 ) ; Yang, C-C; Chen, C-H; Chen, K-H; Sung, P-H; Chen, Y-L; Chai, H-T; Chung, S-Y; Chua, S; Lee, F-Y; Ko, S-F; Lee, M S; Yip, H-K
Abstract:
We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4(D)) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4(D)) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4(D), (3) KIR-F344 (4) KIR-DPP4(D), (5) DPP4(D)-KIR-extendin-9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4(D) rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4(D) than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4(D) rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIR-DPP4(D) and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.
Citation:
DPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning. 2017, 8 (33):54821-54837 Oncotarget
Publisher:
Oncotarget
Journal:
Oncotarget
Issue Date:
15-Aug-2017
URI:
http://hdl.handle.net/11287/620442
DOI:
10.18632/oncotarget.18962
PubMed ID:
28903385
Additional Links:
http://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=18962
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1949-2553
Appears in Collections:
Plastic & Reconstructive Surgery; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorChen, Y-Ten
dc.contributor.authorWallace, Christopher Gen
dc.contributor.authorYang, C-Cen
dc.contributor.authorChen, C-Hen
dc.contributor.authorChen, K-Hen
dc.contributor.authorSung, P-Hen
dc.contributor.authorChen, Y-Len
dc.contributor.authorChai, H-Ten
dc.contributor.authorChung, S-Yen
dc.contributor.authorChua, Sen
dc.contributor.authorLee, F-Yen
dc.contributor.authorKo, S-Fen
dc.contributor.authorLee, M Sen
dc.contributor.authorYip, H-Ken
dc.date.accessioned2017-10-13T14:14:48Z-
dc.date.available2017-10-13T14:14:48Z-
dc.date.issued2017-08-15-
dc.identifier.citationDPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning. 2017, 8 (33):54821-54837 Oncotargeten
dc.identifier.issn1949-2553-
dc.identifier.pmid28903385-
dc.identifier.doi10.18632/oncotarget.18962-
dc.identifier.urihttp://hdl.handle.net/11287/620442-
dc.description.abstractWe analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4(D)) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4(D)) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4(D), (3) KIR-F344 (4) KIR-DPP4(D), (5) DPP4(D)-KIR-extendin-9-39 and (6) BIR-KIR-F344. Blood creatinine and urea nitrogen levels and the urinary protein-to-creatinine ratio was higher in KIR-F344 rats than BIR-KIR-F344 or KIR-DPP4(D) rats 72 h after acute KIR. Conversely, the circulating glucagon-like peptide 1 (GLP-1) levels were higher in BIR-KIR-F344 and KIR-DPP4(D) than KIR-F344 rats after acute KIR. KIR-F344 rats showed greater inflammation, oxidative stress, apoptosis, DNA damage and kidney injury than other rat groups. Damage to the kidney architecture in KIR-F344 rats was greater than in BIR-KIR-F344 or KIR-DPP4(D) rats. Expression of antioxidant proteins and GLP-1 receptor was higher in kidneys from KIR-DPP4(D) and BIR-KIR-F344 than KIR-F344 rats, which suggests better intrinsic responses. We therefore suggest that elevated circulating GLP-1 levels due to DPP4 deficiency and BIR preconditioning protect kidney function and architecture during acute IR injury.en
dc.language.isoenen
dc.publisherOncotargeten
dc.relation.urlhttp://www.impactjournals.com/oncotarget/misc/linkedout.php?pii=18962en
dc.rightsArchived with thanks to Oncotarget. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectWessex Classification Subject Headings::Surgery::Plastic surgeryen
dc.titleDPP-4 enzyme deficiency protects kidney from acute ischemia-reperfusion injury: role for remote intermittent bowel ischemia-reperfusion preconditioning.en
dc.typeJournal Articleen
dc.identifier.journalOncotargeten
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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