The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620444
Title:
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.
Authors:
Munkley, J.; McClurg, U. L.; Livermore, K. E.; Ehrmann, I.; Knight, Bridget; Mccullagh, Paul; McGrath, John S; Crundwell, Malcolm; Harries, L. W.; Leung, H Y; Mills, I. G.; Robson, C. N.; Rajan, P.; Elliott, D. J.
Abstract:
Cell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.
Citation:
The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. 2017, 7 (1):5249 Sci Rep
Publisher:
Nature
Journal:
Scientific Reports
Issue Date:
12-Jul-2017
URI:
http://hdl.handle.net/11287/620444
DOI:
10.1038/s41598-017-05489-5
PubMed ID:
28701765
Additional Links:
http://dx.doi.org/10.1038/s41598-017-05489-5
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
Urology; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMunkley, J.en
dc.contributor.authorMcClurg, U. L.en
dc.contributor.authorLivermore, K. E.en
dc.contributor.authorEhrmann, I.en
dc.contributor.authorKnight, Bridgeten
dc.contributor.authorMccullagh, Paulen
dc.contributor.authorMcGrath, John Sen
dc.contributor.authorCrundwell, Malcolmen
dc.contributor.authorHarries, L. W.en
dc.contributor.authorLeung, H Yen
dc.contributor.authorMills, I. G.en
dc.contributor.authorRobson, C. N.en
dc.contributor.authorRajan, P.en
dc.contributor.authorElliott, D. J.en
dc.date.accessioned2017-10-13T14:26:18Z-
dc.date.available2017-10-13T14:26:18Z-
dc.date.issued2017-07-12-
dc.identifier.citationThe cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. 2017, 7 (1):5249 Sci Repen
dc.identifier.issn2045-2322-
dc.identifier.pmid28701765-
dc.identifier.doi10.1038/s41598-017-05489-5-
dc.identifier.urihttp://hdl.handle.net/11287/620444-
dc.description.abstractCell migration drives cell invasion and metastatic progression in prostate cancer and is a major cause of mortality and morbidity. However the mechanisms driving cell migration in prostate cancer patients are not fully understood. We previously identified the cancer-associated cell migration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostate cancer. Here we find that TSPAN1 is acutely induced by androgens, and is significantly upregulated in prostate cancer relative to both normal prostate tissue and benign prostate hyperplasia (BPH). We also show for the first time, that TSPAN1 expression in prostate cancer cells controls the expression of key proteins involved in cell migration. Stable upregulation of TSPAN1 in both DU145 and PC3 cells significantly increased cell migration and induced the expression of the mesenchymal markers SLUG and ARF6. Our data suggest TSPAN1 is an androgen-driven contributor to cell survival and motility in prostate cancer.en
dc.language.isoenen
dc.publisherNatureen
dc.relation.urlhttp://dx.doi.org/10.1038/s41598-017-05489-5en
dc.rightsArchived with thanks to Scientific reports. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en
dc.subjectWessex Classification Subject Headings::Clinical pathologyen
dc.subjectWessex Classification Subject Headings::Urologyen
dc.titleThe cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration.en
dc.typeJournal Articleen
dc.identifier.journalScientific Reportsen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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