Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620445
Title:
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients.
Authors:
Shields, Beverley M; Shepherd, Maggie ( 0000-0003-2660-0955 ) ; Hudson, M.; McDonald, Timothy J. ( 0000-0003-3559-6660 ) ; Colclough, Kevin; Peters, J.; Knight, Bridget A.; Hyde, C.; Ellard, Sian ( 0000-0002-7620-5526 ) ; Pearson, E. R.; Hattersley, Andrew T.
Abstract:
Monogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately select suitable patients for expensive diagnostic genetic testing. We used C-peptide and islet autoantibodies, highly sensitive and specific biomarkers for discriminating type 1 from non-type 1 diabetes, in a biomarker screening pathway for monogenic diabetes.
Citation:
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients. 2017, 40 (8):1017-1025 Diabetes Care
Publisher:
American Diabetes Association
Journal:
Diabetes Care
Issue Date:
Aug-2017
URI:
http://hdl.handle.net/11287/620445
DOI:
10.2337/dc17-0224
PubMed ID:
28701371
Additional Links:
http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=28701371
Note:
This article is freely available via Open Access via PubMed (accepted manuscript).
Type:
Journal Article
Language:
en
ISSN:
1935-5548
Appears in Collections:
Diabetes/Endocrine Services; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); Molecular Genetics; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShields, Beverley Men
dc.contributor.authorShepherd, Maggieen
dc.contributor.authorHudson, M.en
dc.contributor.authorMcDonald, Timothy J.en
dc.contributor.authorColclough, Kevinen
dc.contributor.authorPeters, J.en
dc.contributor.authorKnight, Bridget A.en
dc.contributor.authorHyde, C.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorPearson, E. R.en
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2017-10-13T14:34:58Z-
dc.date.available2017-10-13T14:34:58Z-
dc.date.issued2017-08-
dc.identifier.citationPopulation-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients. 2017, 40 (8):1017-1025 Diabetes Careen
dc.identifier.issn1935-5548-
dc.identifier.pmid28701371-
dc.identifier.doi10.2337/dc17-0224-
dc.identifier.urihttp://hdl.handle.net/11287/620445-
dc.description.abstractMonogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately select suitable patients for expensive diagnostic genetic testing. We used C-peptide and islet autoantibodies, highly sensitive and specific biomarkers for discriminating type 1 from non-type 1 diabetes, in a biomarker screening pathway for monogenic diabetes.en
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.relation.urlhttp://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=28701371en
dc.rightsArchived with thanks to Diabetes Care. This is the author's manuscript. The final published version is available from Diabetes Care: http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=28701371en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titlePopulation-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients.en
dc.typeJournal Articleen
dc.identifier.journalDiabetes Careen
dc.description.noteThis article is freely available via Open Access via PubMed (accepted manuscript).en
dc.type.versionPublisheden

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