Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients.

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Authors
Shields, Beverley M
Shepherd, Maggie
Hudson, M.
McDonald, Timothy J.
Colclough, Kevin
Peters, J.
Knight, Bridget A.
Hyde, C.
Ellard, Sian
Pearson, E. R.
Journal
Diabetes Care
Type
Journal Article
Publisher
American Diabetes Association
Rights
Archived with thanks to Diabetes Care. This is the author's manuscript. The final published version is available from Diabetes Care: http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=28701371
Monogenic diabetes, a young-onset form of diabetes, is often misdiagnosed as type 1 diabetes, resulting in unnecessary treatment with insulin. A screening approach for monogenic diabetes is needed to accurately select suitable patients for expensive diagnostic genetic testing. We used C-peptide and islet autoantibodies, highly sensitive and specific biomarkers for discriminating type 1 from non-type 1 diabetes, in a biomarker screening pathway for monogenic diabetes.
Citation
Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients. 2017, 40 (8):1017-1025 Diabetes Care
Note
This article is freely available via Open Access via PubMed (accepted manuscript).