Meningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620473
Title:
Meningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab.
Authors:
Parikh, S. R.; Lucidarme, J.; Bingham, Coralie; Warwicker, P.; Goodship, T.; Borrow, R.; Ladhani, S. N.
Abstract:
We describe a case of invasive meningococcal disease due to a vaccine-preventable and penicillin-resistant strain in a fully immunized young adult on long-term complement inhibitor therapy and daily penicillin chemoprophylaxis. Eculizumab is a humanized monoclonal antibody that binds human complement C5 protein and inhibits the terminal complement pathway. It is currently recommended for the treatment of complement-mediated thrombotic microangiopathies. An unwanted complication of inhibiting complement, however, is an increased risk of invasive meningococcal disease. Here, we report the first case of meningococcal group B vaccine failure in a young adult receiving eculizumab for atypical hemolytic uremic syndrome. She developed invasive meningococcal disease due to a vaccine-preventable and penicillin-resistant meningococcal group B strain 4 months after receiving 2 doses of meningococcal group B vaccine while on oral penicillin prophylaxis against meningococcal infection.
Citation:
Meningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab. 2017, 140 (3) Pediatrics
Publisher:
American Academy of Pediatrics
Journal:
Pediatrics
Issue Date:
Sep-2017
URI:
http://hdl.handle.net/11287/620473
DOI:
10.1542/peds.2016-2452
PubMed ID:
28864711
Additional Links:
http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=28864711
Type:
Case Report
Language:
en
ISSN:
1098-4275
Appears in Collections:
Exeter Kidney Unit (Renal); 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorParikh, S. R.en
dc.contributor.authorLucidarme, J.en
dc.contributor.authorBingham, Coralieen
dc.contributor.authorWarwicker, P.en
dc.contributor.authorGoodship, T.en
dc.contributor.authorBorrow, R.en
dc.contributor.authorLadhani, S. N.en
dc.date.accessioned2017-10-26T14:33:16Z-
dc.date.available2017-10-26T14:33:16Z-
dc.date.issued2017-09-
dc.identifier.citationMeningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab. 2017, 140 (3) Pediatricsen
dc.identifier.issn1098-4275-
dc.identifier.pmid28864711-
dc.identifier.doi10.1542/peds.2016-2452-
dc.identifier.urihttp://hdl.handle.net/11287/620473-
dc.description.abstractWe describe a case of invasive meningococcal disease due to a vaccine-preventable and penicillin-resistant strain in a fully immunized young adult on long-term complement inhibitor therapy and daily penicillin chemoprophylaxis. Eculizumab is a humanized monoclonal antibody that binds human complement C5 protein and inhibits the terminal complement pathway. It is currently recommended for the treatment of complement-mediated thrombotic microangiopathies. An unwanted complication of inhibiting complement, however, is an increased risk of invasive meningococcal disease. Here, we report the first case of meningococcal group B vaccine failure in a young adult receiving eculizumab for atypical hemolytic uremic syndrome. She developed invasive meningococcal disease due to a vaccine-preventable and penicillin-resistant meningococcal group B strain 4 months after receiving 2 doses of meningococcal group B vaccine while on oral penicillin prophylaxis against meningococcal infection.en
dc.language.isoenen
dc.publisherAmerican Academy of Pediatricsen
dc.relation.urlhttp://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=28864711en
dc.rightsArchived with thanks to Pediatricsen
dc.subjectWessex Classification Subject Headings::Paediatricsen
dc.subject.meshAdult-
dc.subject.meshAntibodies, Monoclonal, Humanized-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMeningococcal Infections-
dc.subject.meshMeningococcal Vaccines-
dc.subject.meshNeisseria meningitidis, Serogroup B-
dc.subject.meshPenicillin Resistance-
dc.subject.meshPenicillins-
dc.subject.meshYoung Adult-
dc.titleMeningococcal B Vaccine Failure With a Penicillin-Resistant Strain in a Young Adult on Long-Term Eculizumab.en
dc.typeCase Reporten
dc.identifier.journalPediatricsen
dc.type.versionPublisheden

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