Lysyl oxidase and adipose tissue dysfunction

2.50
Hdl Handle:
http://hdl.handle.net/11287/620541
Title:
Lysyl oxidase and adipose tissue dysfunction
Authors:
Pastel, E.; Price, E. J.; Sjöholm, K.; McCulloch, L.J.; Rittig, N.; Liversedge, Neil H.; Knight, Bridget; Møller, N.; Svensson, P-A; Kos, K.
Abstract:
Lysyl oxidase (LOX) is an enzyme crucial for collagen fibre crosslinking and thus for fibrosis development. Fibrosis is characterised by a surplus of collagen fibre accumulation and is amongst others also a feature of obesity-associated dysfunctional adipose tissue (AT) which has been linked with type 2 diabetes. We hypothesised that in type 2 diabetes and obesity LOX expression and activity will be increased as a consequence of worsening AT dysfunction. This study aimed to provide a comprehensive characterisation of LOX in human AT.
Citation:
Lysyl oxidase and adipose tissue dysfunction 2018, 78:118 Metabolism
Publisher:
Elsevier
Journal:
Metabolism
Issue Date:
17-Oct-2017
URI:
http://hdl.handle.net/11287/620541
DOI:
10.1016/j.metabol.2017.10.002
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0026049517302767
Type:
Journal Article
Language:
en
ISSN:
00260495
Appears in Collections:
Obstetrics, Gynaecology & Maternity Services; 2017 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPastel, E.en
dc.contributor.authorPrice, E. J.en
dc.contributor.authorSjöholm, K.en
dc.contributor.authorMcCulloch, L.J.en
dc.contributor.authorRittig, N.en
dc.contributor.authorLiversedge, Neil H.en
dc.contributor.authorKnight, Bridgeten
dc.contributor.authorMøller, N.en
dc.contributor.authorSvensson, P-Aen
dc.contributor.authorKos, K.en
dc.date.accessioned2017-11-22T12:11:21Z-
dc.date.available2017-11-22T12:11:21Z-
dc.date.issued2017-10-17-
dc.identifier.citationLysyl oxidase and adipose tissue dysfunction 2018, 78:118 Metabolismen
dc.identifier.issn00260495-
dc.identifier.doi10.1016/j.metabol.2017.10.002-
dc.identifier.urihttp://hdl.handle.net/11287/620541-
dc.description.abstractLysyl oxidase (LOX) is an enzyme crucial for collagen fibre crosslinking and thus for fibrosis development. Fibrosis is characterised by a surplus of collagen fibre accumulation and is amongst others also a feature of obesity-associated dysfunctional adipose tissue (AT) which has been linked with type 2 diabetes. We hypothesised that in type 2 diabetes and obesity LOX expression and activity will be increased as a consequence of worsening AT dysfunction. This study aimed to provide a comprehensive characterisation of LOX in human AT.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0026049517302767en
dc.rightsArchived with thanks to Metabolismen
dc.subjectWessex Classification Subject Headings::Obstetrics. Midwiferyen
dc.titleLysyl oxidase and adipose tissue dysfunctionen
dc.typeJournal Articleen
dc.identifier.journalMetabolismen
dc.type.versionPublisheden
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