A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620624
Title:
A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.
Authors:
Johnson, M. B.; Patel, K. A.; De Franco, E.; Houghton, Jayne A. L.; McDonald, Timothy J. ( 0000-0003-3559-6660 ) ; Ellard, Sian ( 0000-0002-7620-5526 ) ; Flanagan, S. E.; Hattersley, A. T.
Abstract:
Identifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are present in both monogenic and polygenic aetiologies. We aimed to assess whether a type 1 diabetes genetic risk score (GRS) could identify monogenic autoimmune diabetes and be useful to prioritise individuals for gene discovery studies.
Citation:
A type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes. 2018 Diabetologia
Publisher:
Springer
Journal:
Diabetologia
Issue Date:
7-Feb-2018
URI:
http://hdl.handle.net/11287/620624
DOI:
10.1007/s00125-018-4551-0
PubMed ID:
29417186
Additional Links:
https://dx.doi.org/10.1007/s00125-018-4551-0
Type:
Journal Article
Language:
en
ISSN:
1432-0428
Appears in Collections:
Diabetes/Endocrine Services; Exeter Clinical Laboratory International (Blood Sciences, Genetics, Cellular Pathology & Microbiology); Molecular Genetics; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorJohnson, M. B.en
dc.contributor.authorPatel, K. A.en
dc.contributor.authorDe Franco, E.en
dc.contributor.authorHoughton, Jayne A. L.en
dc.contributor.authorMcDonald, Timothy J.en
dc.contributor.authorEllard, Sianen
dc.contributor.authorFlanagan, S. E.en
dc.contributor.authorHattersley, A. T.en
dc.date.accessioned2018-03-02T15:24:53Z-
dc.date.available2018-03-02T15:24:53Z-
dc.date.issued2018-02-07-
dc.identifier.citationA type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes. 2018 Diabetologiaen
dc.identifier.issn1432-0428-
dc.identifier.pmid29417186-
dc.identifier.doi10.1007/s00125-018-4551-0-
dc.identifier.urihttp://hdl.handle.net/11287/620624-
dc.description.abstractIdentifying individuals suitable for monogenic autoimmunity testing and gene discovery studies is challenging: early-onset type 1 diabetes mellitus can cluster with additional autoimmune diseases due to shared polygenic risk and islet- and other organ-specific autoantibodies are present in both monogenic and polygenic aetiologies. We aimed to assess whether a type 1 diabetes genetic risk score (GRS) could identify monogenic autoimmune diabetes and be useful to prioritise individuals for gene discovery studies.en
dc.language.isoenen
dc.publisherSpringeren
dc.relation.urlhttps://dx.doi.org/10.1007/s00125-018-4551-0en
dc.rightsArchived with thanks to Diabetologiaen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleA type 1 diabetes genetic risk score can discriminate monogenic autoimmunity with diabetes from early-onset clustering of polygenic autoimmunity with diabetes.en
dc.typeJournal Articleen
dc.identifier.journalDiabetologiaen
dc.type.versionIn press (epub ahead of print)en

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