Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations

2.50
Hdl Handle:
http://hdl.handle.net/11287/620634
Title:
Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations
Authors:
Rebbeck, T. R. [et al]; Brewer, Carole
Abstract:
The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on 6 continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database. We observed substantial variation in mutation type and frequency by geographical region and race/ethnicity. In addition to known founder mutations, mutations of relatively high frequency were identified in specific racial/ethnic or geographic groups that may reflect founder mutations and which could be used in targeted (panel) first pass genotyping for specific populations. Knowledge of the population-specific mutational spectrum in BRCA1 and BRCA2 could inform efficient strategies for genetic testing and may justify a more broad-based oncogenetic testing in some populations.
Citation:
Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations. Human Mutation. 2018 Feb 15
Publisher:
Wiley
Journal:
Human Mutation
Issue Date:
15-Feb-2018
URI:
http://hdl.handle.net/11287/620634
DOI:
10.1002/humu.23406
PubMed ID:
29446198
Additional Links:
http://dx.doi.org/10.1002/humu.23406
Type:
Journal Article
Language:
en
Appears in Collections:
Clinical Genetics (Peninsula Genetics); 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRebbeck, T. R. [et al]en
dc.contributor.authorBrewer, Caroleen
dc.date.accessioned2018-03-12T13:16:42Z-
dc.date.available2018-03-12T13:16:42Z-
dc.date.issued2018-02-15-
dc.identifier.citationMutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations. Human Mutation. 2018 Feb 15en
dc.identifier.pmid29446198-
dc.identifier.doi10.1002/humu.23406-
dc.identifier.urihttp://hdl.handle.net/11287/620634-
dc.description.abstractThe prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) has assembled data on 18,435 families with BRCA1 mutations and 11,351 families with BRCA2 mutations ascertained from 69 centers in 49 countries on 6 continents. This study comprehensively describes the characteristics of the 1,650 unique BRCA1 and 1,731 unique BRCA2 deleterious (disease-associated) mutations identified in the CIMBA database. We observed substantial variation in mutation type and frequency by geographical region and race/ethnicity. In addition to known founder mutations, mutations of relatively high frequency were identified in specific racial/ethnic or geographic groups that may reflect founder mutations and which could be used in targeted (panel) first pass genotyping for specific populations. Knowledge of the population-specific mutational spectrum in BRCA1 and BRCA2 could inform efficient strategies for genetic testing and may justify a more broad-based oncogenetic testing in some populations.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://dx.doi.org/10.1002/humu.23406en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleMutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutationsen
dc.typeJournal Articleen
dc.identifier.journalHuman Mutationen
dc.type.versionIn press (epub ahead of print)en

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