Fetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620643
Title:
Fetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight.
Authors:
Hughes, Alice E; Nodzenski, M.; Beaumont, R. N.; Talbot, O.; Shields, B. M.; Scholtens, D. M.; Knight, B. A.; Lowe, W. L.; Hattersley, Andrew T.; Freathy, R. M.
Abstract:
Maternal glycemia is a key determinant of birth weight but recent large-scale genome wide-association studies demonstrated an important contribution of fetal genetics. It is not known whether fetal genotype modifies the impact of maternal glycemia, or whether it acts through insulin-mediated growth. We tested the effects of maternal fasting plasma glucose (FPG) and a fetal genetic score for birth weight on birth weight and fetal insulin in 2,051 European mother-child pairs from the Exeter Family Study of Childhood Health (EFSOCH) and Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. The fetal genetic score influenced birth weight independently of maternal FPG and impacted on growth at all levels of maternal glycemia. For mothers with FPG in the top tertile, the frequency of large for gestational age (LGA, birth weight ≥90thcentile) was 31.1% for offspring with the highest tertile genetic score and only 14.0% with the lowest tertile genetic score. Unlike maternal glucose, the fetal genetic score was not associated with cord insulin or C-peptide. Similar results were seen for HAPO participants of non-European ancestry (n=2,842 pairs). This work demonstrates that for any level of maternal FPG, fetal genetics have a major impact on fetal growth and act predominantly through independent mechanisms.
Citation:
Fetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight. 2018 Diabetes
Publisher:
American Diabetes Association
Journal:
Diabetes
Issue Date:
20-Feb-2018
URI:
http://hdl.handle.net/11287/620643
DOI:
10.2337/db17-1188
PubMed ID:
29463506
Additional Links:
http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=29463506
Type:
Journal Article
Language:
en
ISSN:
1939-327X
Appears in Collections:
Diabetes/Endocrine Services; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHughes, Alice Een
dc.contributor.authorNodzenski, M.en
dc.contributor.authorBeaumont, R. N.en
dc.contributor.authorTalbot, O.en
dc.contributor.authorShields, B. M.en
dc.contributor.authorScholtens, D. M.en
dc.contributor.authorKnight, B. A.en
dc.contributor.authorLowe, W. L.en
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorFreathy, R. M.en
dc.date.accessioned2018-03-21T11:33:04Z-
dc.date.available2018-03-21T11:33:04Z-
dc.date.issued2018-02-20-
dc.identifier.citationFetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight. 2018 Diabetesen
dc.identifier.issn1939-327X-
dc.identifier.pmid29463506-
dc.identifier.doi10.2337/db17-1188-
dc.identifier.urihttp://hdl.handle.net/11287/620643-
dc.description.abstractMaternal glycemia is a key determinant of birth weight but recent large-scale genome wide-association studies demonstrated an important contribution of fetal genetics. It is not known whether fetal genotype modifies the impact of maternal glycemia, or whether it acts through insulin-mediated growth. We tested the effects of maternal fasting plasma glucose (FPG) and a fetal genetic score for birth weight on birth weight and fetal insulin in 2,051 European mother-child pairs from the Exeter Family Study of Childhood Health (EFSOCH) and Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. The fetal genetic score influenced birth weight independently of maternal FPG and impacted on growth at all levels of maternal glycemia. For mothers with FPG in the top tertile, the frequency of large for gestational age (LGA, birth weight ≥90thcentile) was 31.1% for offspring with the highest tertile genetic score and only 14.0% with the lowest tertile genetic score. Unlike maternal glucose, the fetal genetic score was not associated with cord insulin or C-peptide. Similar results were seen for HAPO participants of non-European ancestry (n=2,842 pairs). This work demonstrates that for any level of maternal FPG, fetal genetics have a major impact on fetal growth and act predominantly through independent mechanisms.en
dc.language.isoenen
dc.publisherAmerican Diabetes Associationen
dc.relation.urlhttp://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=29463506en
dc.rightsArchived with thanks to Diabetesen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.titleFetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight.en
dc.typeJournal Articleen
dc.identifier.journalDiabetesen
dc.type.versionIn press (epub ahead of print)en

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