Patient reported outcomes in prospective cohort study of Electrochemotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620644
Title:
Patient reported outcomes in prospective cohort study of Electrochemotherapy.
Authors:
Al-Hadithy, N; Dehnel, Alexandra; George, Alexander; Kisiel, Robert; Lunt, Craig; Stone, Christopher
Abstract:
Metastatic spread of malignant tumours to skin is a well described phenomenon with incidence of approximately 0.7-9% of all metastases depending on histological type of primary cancer. Electrochemotherapy (ECT) is an efficient local tumour ablation modality that has proven clinical efficacy in the treatment of various types of tumours metastasis to skin. Aims of this study are to evaluate the activity, toxicity, and feasibility of treating patients with electrochemotherapy (ECT); their clinical outcomes and patient report outcome measures. This was a cohort study of 48 patients. In this study a good or excellent response to treatment was observed in 74% of patients on the basis of the clinical photographs. Five patients had partial responses (14%) and three patients had no response (8.5%). One patient died during the study period (2.8%). 87% of patients said they would have ECT again if clinically indicated. Spearman's' rank correlation of clinical efficacy for anatomical location was found to be positive with poorer outcomes in head and neck compared to trunk and limbs. Complications were found in 16patients, of which all were either grade 1 or 2 Clavien classification. The complications were predominantly in patients treated with ECT for tumours the head and neck area. Initial assessment of applicable patient report outcome measures for our patient cohort demonstrate that there are no validated tools exist for ECT. Further work is required here.
Citation:
Patient reported outcomes in prospective cohort study of Electrochemotherapy. 2018, 52:110-119 Int J Surg
Publisher:
Elsevier
Journal:
International journal of surgery (London, England)
Issue Date:
21-Feb-2018
URI:
http://hdl.handle.net/11287/620644
DOI:
10.1016/j.ijsu.2018.02.040
PubMed ID:
29474886
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S1743-9191(18)30570-3
Type:
Journal Article
Language:
en
ISSN:
1743-9159
Appears in Collections:
Plastic & Reconstructive Surgery; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorAl-Hadithy, Nen
dc.contributor.authorDehnel, Alexandraen
dc.contributor.authorGeorge, Alexanderen
dc.contributor.authorKisiel, Roberten
dc.contributor.authorLunt, Craigen
dc.contributor.authorStone, Christopheren
dc.date.accessioned2018-03-21T11:36:15Z-
dc.date.available2018-03-21T11:36:15Z-
dc.date.issued2018-02-21-
dc.identifier.citationPatient reported outcomes in prospective cohort study of Electrochemotherapy. 2018, 52:110-119 Int J Surgen
dc.identifier.issn1743-9159-
dc.identifier.pmid29474886-
dc.identifier.doi10.1016/j.ijsu.2018.02.040-
dc.identifier.urihttp://hdl.handle.net/11287/620644-
dc.description.abstractMetastatic spread of malignant tumours to skin is a well described phenomenon with incidence of approximately 0.7-9% of all metastases depending on histological type of primary cancer. Electrochemotherapy (ECT) is an efficient local tumour ablation modality that has proven clinical efficacy in the treatment of various types of tumours metastasis to skin. Aims of this study are to evaluate the activity, toxicity, and feasibility of treating patients with electrochemotherapy (ECT); their clinical outcomes and patient report outcome measures. This was a cohort study of 48 patients. In this study a good or excellent response to treatment was observed in 74% of patients on the basis of the clinical photographs. Five patients had partial responses (14%) and three patients had no response (8.5%). One patient died during the study period (2.8%). 87% of patients said they would have ECT again if clinically indicated. Spearman's' rank correlation of clinical efficacy for anatomical location was found to be positive with poorer outcomes in head and neck compared to trunk and limbs. Complications were found in 16patients, of which all were either grade 1 or 2 Clavien classification. The complications were predominantly in patients treated with ECT for tumours the head and neck area. Initial assessment of applicable patient report outcome measures for our patient cohort demonstrate that there are no validated tools exist for ECT. Further work is required here.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1743-9191(18)30570-3en
dc.rightsArchived with thanks to International journal of surgery (London, England)en
dc.subjectWessex Classification Subject Headings::Surgery::Plastic surgeryen
dc.titlePatient reported outcomes in prospective cohort study of Electrochemotherapy.en
dc.typeJournal Articleen
dc.identifier.journalInternational journal of surgery (London, England)en
dc.type.versionPublisheden

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