Elevated polygenic burden for autism is associated with differential DNA methylation at birth.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620678
Title:
Elevated polygenic burden for autism is associated with differential DNA methylation at birth.
Authors:
Hannon, E. [et al] inc.; Mill, Jonathan
Abstract:
Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.
Citation:
Elevated polygenic burden for autism is associated with differential DNA methylation at birth. 2018, 10 (1):19 Genome Med
Publisher:
BioMed Central
Journal:
Genome medicine
Issue Date:
28-Mar-2018
URI:
http://hdl.handle.net/11287/620678
DOI:
10.1186/s13073-018-0527-4
PubMed ID:
29587883
Additional Links:
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-018-0527-4
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1756-994X
Appears in Collections:
Honorary contracts publications; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHannon, E. [et al] inc.en
dc.contributor.authorMill, Jonathanen
dc.date.accessioned2018-05-08T08:35:30Z-
dc.date.available2018-05-08T08:35:30Z-
dc.date.issued2018-03-28-
dc.identifier.citationElevated polygenic burden for autism is associated with differential DNA methylation at birth. 2018, 10 (1):19 Genome Meden
dc.identifier.issn1756-994X-
dc.identifier.pmid29587883-
dc.identifier.doi10.1186/s13073-018-0527-4-
dc.identifier.urihttp://hdl.handle.net/11287/620678-
dc.description.abstractAutism spectrum disorder (ASD) is a severe neurodevelopmental disorder characterized by deficits in social communication and restricted, repetitive behaviors, interests, or activities. The etiology of ASD involves both inherited and environmental risk factors, with epigenetic processes hypothesized as one mechanism by which both genetic and non-genetic variation influence gene regulation and pathogenesis. The aim of this study was to identify DNA methylation biomarkers of ASD detectable at birth.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://genomemedicine.biomedcentral.com/articles/10.1186/s13073-018-0527-4en
dc.rightsArchived with thanks to Genome medicineen
dc.subjectWessex Classification Subject Headings::Mental healthen
dc.titleElevated polygenic burden for autism is associated with differential DNA methylation at birth.en
dc.typeJournal Articleen
dc.identifier.journalGenome medicineen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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