Clinical applications of infrared and Raman spectroscopy: state of play and future challenges.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620688
Title:
Clinical applications of infrared and Raman spectroscopy: state of play and future challenges.
Authors:
Baker, M. J. [et al[ inc.; Stone, Nick
Abstract:
Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolutionise our clinical systems leading to improved patient outcome, more efficient public services and significant economic savings. However, despite these strong drivers, there are many fundamental scientific and technological challenges which have limited the implementation of this technology in the clinical arena, although recent years have seen significant progress in addressing these challenges. This review examines (i) the state of the art of clinical applications of infrared absorption and Raman spectroscopy, and (ii) the outstanding challenges, and progress towards translation, highlighting specific examples in the areas of in vivo, ex vivo and in vitro applications. In addition, the requirements of instrumentation suitable for use in the clinic, strategies for pre-processing and statistical analysis in clinical spectroscopy and data sharing protocols, will be discussed. Emerging consensus recommendations are presented, and the future perspectives of the field are assessed, particularly in the context of national and international collaborative research initiatives, such as the UK EPSRC Clinical Infrared and Raman Spectroscopy Network, the EU COST Action Raman4Clinics, and the International Society for Clinical Spectroscopy.
Citation:
Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. 2018, 143 (8):1735-1757 Analyst
Publisher:
Royal Society of Chemistry
Journal:
The Analyst
Issue Date:
16-Apr-2018
URI:
http://hdl.handle.net/11287/620688
DOI:
10.1039/c7an01871a
PubMed ID:
29504623
Additional Links:
http://dx.doi.org/10.1039/c7an01871a
Type:
Journal Article
Language:
en
ISSN:
1364-5528
Appears in Collections:
Honorary contracts publications; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBaker, M. J. [et al[ inc.en
dc.contributor.authorStone, Nicken
dc.date.accessioned2018-05-08T09:18:21Z-
dc.date.available2018-05-08T09:18:21Z-
dc.date.issued2018-04-16-
dc.identifier.citationClinical applications of infrared and Raman spectroscopy: state of play and future challenges. 2018, 143 (8):1735-1757 Analysten
dc.identifier.issn1364-5528-
dc.identifier.pmid29504623-
dc.identifier.doi10.1039/c7an01871a-
dc.identifier.urihttp://hdl.handle.net/11287/620688-
dc.description.abstractVibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolutionise our clinical systems leading to improved patient outcome, more efficient public services and significant economic savings. However, despite these strong drivers, there are many fundamental scientific and technological challenges which have limited the implementation of this technology in the clinical arena, although recent years have seen significant progress in addressing these challenges. This review examines (i) the state of the art of clinical applications of infrared absorption and Raman spectroscopy, and (ii) the outstanding challenges, and progress towards translation, highlighting specific examples in the areas of in vivo, ex vivo and in vitro applications. In addition, the requirements of instrumentation suitable for use in the clinic, strategies for pre-processing and statistical analysis in clinical spectroscopy and data sharing protocols, will be discussed. Emerging consensus recommendations are presented, and the future perspectives of the field are assessed, particularly in the context of national and international collaborative research initiatives, such as the UK EPSRC Clinical Infrared and Raman Spectroscopy Network, the EU COST Action Raman4Clinics, and the International Society for Clinical Spectroscopy.en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.urlhttp://dx.doi.org/10.1039/c7an01871aen
dc.rightsArchived with thanks to The Analysten
dc.subjectWessex Classification Subject Headings::Clinical pathologyen
dc.titleClinical applications of infrared and Raman spectroscopy: state of play and future challenges.en
dc.typeJournal Articleen
dc.identifier.journalThe Analysten
dc.type.versionPublisheden

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