Diabetes, cardiovascular disease and the microcirculation.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620710
Title:
Diabetes, cardiovascular disease and the microcirculation.
Authors:
Strain, David; Paldánius, P M
Abstract:
Cardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes. In this contribution, we aim to review the changes observed in the vascular tree in people with T2DM compared to the general population, the effects of established anti-diabetes drugs on microvascular outcomes, and explore the hypotheses to account for common causalities of the increased prevalence of CVD and hypertension in people with T2DM.
Citation:
Diabetes, cardiovascular disease and the microcirculation. 2018, 17 (1):57 Cardiovasc Diabetol
Publisher:
BioMed Central
Journal:
Cardiovascular diabetology
Issue Date:
18-Apr-2018
URI:
http://hdl.handle.net/11287/620710
DOI:
10.1186/s12933-018-0703-2
PubMed ID:
29669543
Additional Links:
https://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0703-2
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.
Type:
Journal Article
Language:
en
ISSN:
1475-2840
Appears in Collections:
Healthcare for Older People; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorStrain, Daviden
dc.contributor.authorPaldánius, P Men
dc.date.accessioned2018-06-20T15:18:16Z-
dc.date.available2018-06-20T15:18:16Z-
dc.date.issued2018-04-18-
dc.identifier.citationDiabetes, cardiovascular disease and the microcirculation. 2018, 17 (1):57 Cardiovasc Diabetolen
dc.identifier.issn1475-2840-
dc.identifier.pmid29669543-
dc.identifier.doi10.1186/s12933-018-0703-2-
dc.identifier.urihttp://hdl.handle.net/11287/620710-
dc.description.abstractCardiovascular disease (CVD) is the leading cause of mortality in people with type 2 diabetes mellitus (T2DM), yet a significant proportion of the disease burden cannot be accounted for by conventional cardiovascular risk factors. Hypertension occurs in majority of people with T2DM, which is substantially more frequent than would be anticipated based on general population samples. The impact of hypertension is considerably higher in people with diabetes than it is in the general population, suggesting either an increased sensitivity to its effect or a confounding underlying aetiopathogenic mechanism of hypertension associated with CVD within diabetes. In this contribution, we aim to review the changes observed in the vascular tree in people with T2DM compared to the general population, the effects of established anti-diabetes drugs on microvascular outcomes, and explore the hypotheses to account for common causalities of the increased prevalence of CVD and hypertension in people with T2DM.en
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://cardiab.biomedcentral.com/articles/10.1186/s12933-018-0703-2en
dc.rightsArchived with thanks to Cardiovascular diabetology. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en
dc.subjectWessex Classification Subject Headings::Eldery care.en
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleDiabetes, cardiovascular disease and the microcirculation.en
dc.typeJournal Articleen
dc.identifier.journalCardiovascular diabetologyen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.en
dc.type.versionPublisheden

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