Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620748
Title:
Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment.
Authors:
Misra, S; Vedovato, N; Cliff, E; De Franco, Elisa; Hattersley, Andrew T.; Ashcroft, F M; Oliver, N S
Abstract:
Permanent neonatal diabetes caused by mutations in the KCNJ11 gene may be managed with high-dose sulfonylureas. Complete transfer to sulfonylureas is not successful in all cases and can result in insulin monotherapy. In such cases, the outcomes of combining sulfonylureas with insulin have not been fully explored. We present the case of a woman with diabetes due to a KCNJ11 mutation, in whom combination therapy led to clinically meaningful improvements.
Citation:
Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment. 2018 Jun 13 Diabet. Med.
Publisher:
Wiley
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Issue Date:
13-Jun-2018
URI:
http://hdl.handle.net/11287/620748
DOI:
10.1111/dme.13758
PubMed ID:
29896782
Additional Links:
http://dx.doi.org/10.1111/dme.13758
Type:
Case Report
Language:
en
ISSN:
1464-5491
Appears in Collections:
Diabetes/Endocrine Services; Molecular Genetics; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMisra, Sen
dc.contributor.authorVedovato, Nen
dc.contributor.authorCliff, Een
dc.contributor.authorDe Franco, Elisaen
dc.contributor.authorHattersley, Andrew T.en
dc.contributor.authorAshcroft, F Men
dc.contributor.authorOliver, N Sen
dc.date.accessioned2018-07-10T11:18:32Z-
dc.date.available2018-07-10T11:18:32Z-
dc.date.issued2018-06-13-
dc.identifier.citationPermanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment. 2018 Jun 13 Diabet. Med.en
dc.identifier.issn1464-5491-
dc.identifier.pmid29896782-
dc.identifier.doi10.1111/dme.13758-
dc.identifier.urihttp://hdl.handle.net/11287/620748-
dc.description.abstractPermanent neonatal diabetes caused by mutations in the KCNJ11 gene may be managed with high-dose sulfonylureas. Complete transfer to sulfonylureas is not successful in all cases and can result in insulin monotherapy. In such cases, the outcomes of combining sulfonylureas with insulin have not been fully explored. We present the case of a woman with diabetes due to a KCNJ11 mutation, in whom combination therapy led to clinically meaningful improvements.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://dx.doi.org/10.1111/dme.13758en
dc.rightsArchived with thanks to Diabetic medicine : a journal of the British Diabetic Associationen
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titlePermanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment.en
dc.typeCase Reporten
dc.identifier.journalDiabetic medicine : a journal of the British Diabetic Associationen
dc.type.versionIn press (epub ahead of print)en

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