Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620815
Title:
Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.
Authors:
Richardson, S. J.; Morgan, Noel
Abstract:
The development of islet autoimmunity and type 1 diabetes has long been linked with enteroviral infection but a causal relationship has proven hard to establish. This is partly because much of the epidemiological evidence derives from studies of neutralising antibody generation in blood samples while less attention has been paid to the pancreatic beta cell as a site of infection. Nevertheless, recent studies have revealed that beta cells express specific enteroviral receptors and that they can sustain a productive enteroviral infection. Importantly, they can also mount antiviral responses which attenuate viral replication and may favour the establishment of a persistent enteroviral infection. Together, these responses combine to create the Trojan horse by which enteroviruses might precipitate islet autoimmunity.
Citation:
Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. 2018, 43:11-19 Curr Opin Pharmacol
Publisher:
Elsevier
Journal:
Current opinion in pharmacology
Issue Date:
28-Jul-2018
URI:
http://hdl.handle.net/11287/620815
DOI:
10.1016/j.coph.2018.07.006
PubMed ID:
30064099
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(17)30220-5
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full text.
Type:
Journal Article
Language:
en
ISSN:
1471-4973
Appears in Collections:
Honorary contracts publications; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRichardson, S. J.en
dc.contributor.authorMorgan, Noelen
dc.date.accessioned2018-09-25T14:18:31Z-
dc.date.available2018-09-25T14:18:31Z-
dc.date.issued2018-07-28-
dc.identifier.citationEnteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. 2018, 43:11-19 Curr Opin Pharmacolen
dc.identifier.issn1471-4973-
dc.identifier.pmid30064099-
dc.identifier.doi10.1016/j.coph.2018.07.006-
dc.identifier.urihttp://hdl.handle.net/11287/620815-
dc.description.abstractThe development of islet autoimmunity and type 1 diabetes has long been linked with enteroviral infection but a causal relationship has proven hard to establish. This is partly because much of the epidemiological evidence derives from studies of neutralising antibody generation in blood samples while less attention has been paid to the pancreatic beta cell as a site of infection. Nevertheless, recent studies have revealed that beta cells express specific enteroviral receptors and that they can sustain a productive enteroviral infection. Importantly, they can also mount antiviral responses which attenuate viral replication and may favour the establishment of a persistent enteroviral infection. Together, these responses combine to create the Trojan horse by which enteroviruses might precipitate islet autoimmunity.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1471-4892(17)30220-5en
dc.rightsArchived with thanks to Current opinion in pharmacologyen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleEnteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention.en
dc.typeJournal Articleen
dc.identifier.journalCurrent opinion in pharmacologyen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full text.en
dc.type.versionPublisheden

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