Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620842
Title:
Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.
Authors:
Chakera, A. J. [et al]; Hattersley, Andrew T.
Abstract:
Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key counter-regulatory hormones glucagon and epinephrine that together promote endogenous glucose production to restore normoglycemia. However, specifically how this response is orchestrated remains to be fully clarified. The low affinity hexokinase glucokinase is found in glucose-sensing cells involved in glucose homeostasis including pancreatic β-cells and in certain brain areas. Here, we aimed to examine the role of glucokinase in triggering counter-regulatory hormonal responses to hypoglycemia, hypothesizing that reduced glucokinase activity would lead to increased and/or earlier triggering of responses.
Citation:
Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. 2018 Mol Metab
Publisher:
Elsevier
Journal:
Molecular metabolism
Issue Date:
13-Aug-2018
URI:
http://hdl.handle.net/11287/620842
DOI:
10.1016/j.molmet.2018.08.001
PubMed ID:
30146176
Additional Links:
https://linkinghub.elsevier.com/retrieve/pii/S2212-8778(18)30750-6
Note:
This article is freely available via Open Access. Click on the Additional Link above to access the full-text.
Type:
Journal Article
Language:
en
ISSN:
2212-8778
Appears in Collections:
Diabetes/Endocrine Services; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorChakera, A. J. [et al]en
dc.contributor.authorHattersley, Andrew T.en
dc.date.accessioned2018-10-04T09:16:20Z-
dc.date.available2018-10-04T09:16:20Z-
dc.date.issued2018-08-13-
dc.identifier.citationMolecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. 2018 Mol Metaben
dc.identifier.issn2212-8778-
dc.identifier.pmid30146176-
dc.identifier.doi10.1016/j.molmet.2018.08.001-
dc.identifier.urihttp://hdl.handle.net/11287/620842-
dc.description.abstractAppropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key counter-regulatory hormones glucagon and epinephrine that together promote endogenous glucose production to restore normoglycemia. However, specifically how this response is orchestrated remains to be fully clarified. The low affinity hexokinase glucokinase is found in glucose-sensing cells involved in glucose homeostasis including pancreatic β-cells and in certain brain areas. Here, we aimed to examine the role of glucokinase in triggering counter-regulatory hormonal responses to hypoglycemia, hypothesizing that reduced glucokinase activity would lead to increased and/or earlier triggering of responses.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2212-8778(18)30750-6en
dc.rightsArchived with thanks to Molecular metabolism. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en
dc.subjectWessex Classification Subject Headings::Oncology. Pathology.::Geneticsen
dc.subjectWessex Classification Subject Headings::Endocrinology::Diabetesen
dc.titleMolecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.en
dc.typeJournal Articleen
dc.identifier.journalMolecular metabolismen
dc.description.noteThis article is freely available via Open Access. Click on the Additional Link above to access the full-text.en
dc.type.versionIn press (epub ahead of print)en

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