Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.

2.50
Hdl Handle:
http://hdl.handle.net/11287/620853
Title:
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.
Authors:
Pranjol, M. Z. I.; Gutowski, Nicholas J.; Hannemann, Michael; Whatmore, J. L.
Abstract:
Metastasis still remains the major cause of therapeutic failure, poor prognosis and high mortality in epithelial ovarian cancer (EOC) patients. Previously, we showed that EOC cells secrete a range of factors with potential pro-angiogenic activity, in disease-relevant human microvascular omental endothelial cells (HOMECs), including the lysosomal protease cathepsin L (CathL). Thus, the aim of this study was to examine potential pro-proliferative and pro-migratory effects of CathL in HOMECs and the activated signalling pathways, and whether these proangiogenic responses are dependent on CathL-catalytic activity.
Citation:
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway. 2018 Curr Cancer Drug Targets
Publisher:
Bentham Science
Journal:
Current cancer drug targets
Issue Date:
31-Aug-2018
URI:
http://hdl.handle.net/11287/620853
DOI:
10.2174/1568009618666180831123951
PubMed ID:
30173647
Additional Links:
http://www.eurekaselect.com/165035/article
Type:
Journal Article
Language:
en
ISSN:
1873-5576
Appears in Collections:
Neurology; Obstetrics, Gynaecology & Maternity Services; 2018 RD&E publications

Full metadata record

DC FieldValue Language
dc.contributor.authorPranjol, M. Z. I.en
dc.contributor.authorGutowski, Nicholas J.en
dc.contributor.authorHannemann, Michaelen
dc.contributor.authorWhatmore, J. L.en
dc.date.accessioned2018-10-04T11:31:02Z-
dc.date.available2018-10-04T11:31:02Z-
dc.date.issued2018-08-31-
dc.identifier.citationCathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway. 2018 Curr Cancer Drug Targetsen
dc.identifier.issn1873-5576-
dc.identifier.pmid30173647-
dc.identifier.doi10.2174/1568009618666180831123951-
dc.identifier.urihttp://hdl.handle.net/11287/620853-
dc.description.abstractMetastasis still remains the major cause of therapeutic failure, poor prognosis and high mortality in epithelial ovarian cancer (EOC) patients. Previously, we showed that EOC cells secrete a range of factors with potential pro-angiogenic activity, in disease-relevant human microvascular omental endothelial cells (HOMECs), including the lysosomal protease cathepsin L (CathL). Thus, the aim of this study was to examine potential pro-proliferative and pro-migratory effects of CathL in HOMECs and the activated signalling pathways, and whether these proangiogenic responses are dependent on CathL-catalytic activity.en
dc.language.isoenen
dc.publisherBentham Scienceen
dc.relation.urlhttp://www.eurekaselect.com/165035/articleen
dc.rightsArchived with thanks to Current cancer drug targetsen
dc.subjectWessex Classification Subject Headings::Gynaecologyen
dc.titleCathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.en
dc.typeJournal Articleen
dc.identifier.journalCurrent cancer drug targetsen
dc.type.versionIn press (epub ahead of print)en
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